論文・学術誌 / Publications

2015～2024 | 2010～2014 | 2005～2009 | 特許

2024年
    1. 橋本剛, 高橋あかね,
      "JASIS 2023 見聞録 (Japan Analytical & Scientific Instruments Show)",
      ぶんせき, 1, 34-36 (2024).
      https://bunseki.jsac.jp/archives/4300
    2. 橋本剛, 市場有子,
      "株式会社島津製作所Shimadzu Tokyo Innovation Plazaを訪ねて",
      ぶんせき, 1, 30-32 (2024).
      https://bunseki.jsac.jp/archives/4300
2023年 2022年
    1. "Synthesis and Antioxidant Activity of Silver Nanoparticles using the Odontonema strictum Leaf Extract"
      Lokadi Pierre Luhata, Christian Nanga Chick, Natsuki Mori, Kunihito Tanaka, Hiroshi Uchida, Takashi Hayashita, and Toyonobu Usuki,
      Molecules, 2022, 27(10), 3210. DOI: 10.3390/molecules27103210
    2. "Marcus model-based analysis of the photo-quenching mechanism of a boronic acid fluorophore: water concentration dependence of electron transfer rate"
      Ryohei Yoshinaga, Fuya Kojima, Kazuma Sugiyama, Hideyuki Kunugita, Takeshi Hashimoto, Takashi Hayashita, and Kazuhiro Ema,
      Anal. Sci., (2022). DOI: 10.1007/s44211-022-00222-3
    3. "Fluorescence Detection of Endotoxin Using Cadmium Complexed with Dipicolylamine-type Pyrene Probe"
      Hiroshi Kimoto, Masamitsu Iiyama, Takeshi Hashimoto, and Takashi Hayashita,
      J. ION EXCHANGE, 2022, 33, 95-99. DOI: 10.5182/jaie.33.95
    4. "Boric Acid Detection in Water by Gallacetophenone"
      Kai Sato, Hiroshi Kimoto, Takeshi Hashimoto, and Takashi Hayashita,
      J. ION EXCHANGE, 2022, 33, 100-104. DOI: 10.5182/jaie.33.100
    5. "Boronic Acid-Based Dendrimers with Various Surface Properties for Bacterial Recognition with Adjustable Selectivity"
      Ayame Mikagi, Koichi Manita, Yuji Tsuchido, Nobuyuki Kanzawa, Takeshi Hashimoto, and Takashi Hayashita,
      ACS Appl. Bio Mater., 2022, 5, 5255-5263. DOI: 10.1021/acsabm.2c00680
      Selected as 'Supplementary Cover'
      　　　
    6. "A Simple Supramolecular Complex of Boronic Acid-appended b-Cyclodextrion and a Fluorescent Boronic Acid-based Probe with Excellent Selectivity for D-Glucose in Water"
      Ko Sugita, Yota Suzuki, Yuji Tsuchido, Shoji Fujiwara, Takeshi Hashimoto, and Takashi Hayashita,
      RSC Adv., 2022, 12, 20259-20263. DOI: 10.1039/d2ra03567g
    7. "Simple and Rapid Endotoxin Recognition Using Dipicolylamine-Modified Fluorescent Probe with Picomolar-Order Sensitivity"
      Hiroshi Kimoto, Yota Suzuki, Yu Ebisawa, Masamitsu Iiyama, Takeshi Hashimoto, and Takashi Hayashita,
      ACS Omega, 2022, 7, 25891-25897. DOI: 10.1021/acsomega.2c02935
      Selected as 'Supplementary Cover'
      　　　
    8. "NMR Investigation of the Supramolecular Complex Formed by a Phenylboronic Acid-Ferrocene Electroactive Probe and Native or Derivatized β-Cyclodextrin"
      Andrea Cesari, Maria Antonietta Casulli, Takeshi Hashimoto, and Takashi Hayashita,
      Int. J. Mol. Sci., 2022, 23, 6045. DOI: 10.3390/ijms23116045
    9. ジピコリルアミン配位子を修飾したポリアミドアミンデンドリマー試薬によるリン酸誘導体認識
      橋本 剛, 田淵 直人, 早下 隆士
      分析化学, 2022, 71, 167-178. DOI: 10.2116/bunsekikagaku.71.167
    10. "Ratiometric fluorescence sensing of d-allulose using an inclusion complex of γ-cyclodextrin with a benzoxaborole-based probe"
      Yota Suzuki, Takeshi Hashimoto, and Takashi Hayashita,
      RSC Adv., 2022, 12, 12145-12151. DOI: 10.1039/d2ra00749e
    11. "Rapid Bacterial Recognition over a Wide pH Range by Boronic Acid-Based Ditopic Dendrimer Probes for Gram-Positive Bacteria"
      Ayame Mikagi, Koichi Manita, Asuka Yoyasu, Yuji Tsuchido, Nobuyuki Kanzawa, Takeshi Hashimoto, and Takashi Hayashita,
      Molecules, 2022, 27(1), 256. DOI: 10.3390/molecules27010256
2021年
    1. Agustina Sus Andreani, Eko Sri Kunarti, Takeshi Hashimoto, Takashi Hayashita, and Sri Juari Santosa
      "Fast and selective colorimetric detection of Fe3+ based on gold nanoparticles capped with ortho-hydroxybenzoic acid",
      Journal of Environmental Chemical Engineering, 9, 105962 (2021). DOI: 10.1016/j.jece.2021.105962
    2. Shohei Minagawa, Shoji Fujiwara, Takeshi Hashimoto, and Takashi Hayashita,
      "Supramolecular Zn(II)-Dipicolylamine-Azobenzene-Aminocyclodextrin-ATP Complex: Design and ATP Recognition in Water",
      Int. J. Mol. Sci., 22, 4683 (2021). DOI: 10.3390/ijms22094683
    3. Hiroshi Kimoto and Koshi Yamamoto,
      "The influence of hypoxia on the distribution of dissolved bioactive trace metals in Mikawa Bay, central Japan",
      Geochemical Journal, 55, 159-170 (2021). DOI: 10.2343/geochemj.2.0625
    4. Ayame Mikagi, Riho Tsurufusa, Yuji Tsuchido, Takeshi Hashimoto, and Takashi Hayashita,
      "Fast and Sensitive Bacteria Detection by Boronic Acid Modified Fluorescent Dendrimer",
      Sensors, 21, 3115 (2021). DOI: 10.3390/s21093115
    5. Maria Antonietta Casulli, Irene Taurino, Takeshi Hashimoto, Sandro Carrara, and Takashi Hayashita,
      "Electrochemical Sensing of Adenosine Triphosphate by Specific Binding to Dipicolylamine Group in Cyclodextrin Supramolecular Complex",
      ACS Appl. Bio Mater., 4(4), 3041-3045 (2021). DOI: 10.1021/acsabm.1c00166
    6. Ayame Mikagi and Takashi Hayashita,
      "超分子ナノ構造体の設計と細菌識別技術",
      化学工業, 72(6), 109-116 (2021).
    7. Yuji Tsuchido, Nana Nodomi, Takeshi Hashimoto, and Takashi Hayashita,
      "Micelle Type Sensor for Saccharide Recognition by Using Boronic Acid Fluorescence Amphiphilic Probe and Surfactants",
      Solv. Extr. Ion Exch., in press. DOI: 10.1080/07366299.2021.1876988
    8. Yuji Tsuchido, Shohei Kojima, Ko Sugita, Shoji Fujiwara, Takeshi Hashimoto, and Takashi Hayashita,
      "Effect of Spacer Length in Pyrene-Modified-Phenylboronic Acid Probe/CyD Complexes on Fluorescence-based Recognition of Monosaccharides in Aqueous Solution",
      Anal. Sci., 37(5), 721 (2021). DOI: 10.2116/analsci.20SCP08
2020年
    1. Maria Antonietta Casulli, Irene Taurino, Takeshi Hashimoto, Sandro Carrara and Takashi Hayashita,
      "Electrochemical Assay for Extremely Selective Recognition of Fructose Based on 4-Ferrocene-Phenylboronic Acid probe and β-Cyclodextrins Supramolecular Complex",
      Small, 16, 2003359 (2020). DOI: 10.1002/smll.202003359
    2. Kazusa Aoki, Ryuji Osako, Jiahui Deng, Takashi Hayashita, Takeshi Hashimoto and Yumiko Suzuki,
      "Phosphate-sensing with (di-(2-picolyl)amino) quinazolines based on a fluorescence on–off system",
      RSC Adv., 10, 15299-15306 (2020). DOI: 10.1039/d0ra01455a
    3. Kenta Hagiwara, Hiroshi Uchida, Yumiko Suzuki, Takashi Hayashita, Kanjiro Torigoe, Tetsuya Kida and Satoshi Horikoshi,
      "Role of alkan-1-ol solvents in the synthesis of yellow luminescent carbon quantum dots (CQDs): van der Waals force-caused aggregation and agglomeration",
      RSC Adv., 10, 14396-14402 (2020). DOI: 10.1039/d0ra01349h
    4. Takeshi Hashimoto, Mio Kumai, Mariko Maeda, Koji Miyoshi, Yuji Tsuchido, Shoji Fujiwara, and Takashi Hayashita,
      "Structural Effect of Fluorophore on Phenylboronic Acid Fluorophore/Cyclodextrin Complex for Selective Glucose Recognition",
      Front. Chem. Sci. Eng., 14, 53-60 (2020). DOI: 10.1007/s11705-019-1851-y
2019年
    1. Maria Antonietta Casulli, Irene Taurino, Sandro Carrara, and Takashi Hayashita,
      "Integration Methods of Cyclodextrins on Gold and Carbon Electrodes for Electrochemical Sensors",
      J. Carbon Res., 5, 78 (2019). DOI: 10.3390/c5040078
    2. Ko Sugita, Yuji Tsuchido, Chisato Kasahara, Maria Antonietta Casulli, Shoji Fujiwara, Takeshi Hashimoto, and Takashi Hayashita,
      "Selective Sugar Recognition by Anthracene-Type Boronic Acid Fluorophore/Cyclodextrin Supramolecular Complex under Physiological pH Condition",
      Front. Chem., 7, 806 (2019). DOI: 10.3389/fchem.2019.00806
    3. Yuji Tsuchido, Ryosuke Horiuchi, Takeshi Hashimoto, Kanako Ishihara, Nobuyuki Kanzawa, and Takashi Hayashita,
      "Rapid and Selective Discrimination of Gram-Positive and Gram-Negative Bacteria by Boronic Acid Modified Polyamidoamine Dendrimer",
      Anal. Chem., 91(6), 3929-3935 (2019). DOI: 10.1021/acs.analchem.8b04870
      Selected as 'Supplementary Cover'
      Supplementary Cover, Anal. Chem., 2019, Issue 6
    4. Keiko Takahashi, and Takashi Hayashita,
      "Special issue "cyclodextrins: past, present, and future"",
      J. Incl. Phenom. Macrocycl. Chem., 93, 1 (2019). （Editorial） DOI: 10.1007/s10847-018-0860-7
    5. Takayuki Goto, Yukihiro Kitamoto, Kazuki Matsui, Haruhiko Kuroe, Akira Endo, Takeshi Hashimoto, Takashi Hayashita, Satoshi Iguchi, and Takahiko Sasaki,
      "Low-Temperature Magnetism of Gold Nano Particles Contained in Electrochemical Sugar Recognition System",
      IEEE Transactions on Magnetics, 55(2), 2300404 (2019). DOI: 10.1109/TMAG.2018.2872134
2018年
    1. Adam C. Sedgwick, Luling Wu, Hai-Hao Han, Steven D. Bull, Xiao-Peng He, Tony D. James, Jonathan L. Sessler, Ben Zhong Tang, He Tian, and Juyoung Yoon,
      "Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents",
      Chem. Soc. Rev., 47(23), 8842-8880 (2018). DOI: 10.1039/C8CS00185E
    2. Shoji Fujiwara, Kentaro Nonaka, Mai Yamaguchi, Takeshi Hashimoto, and Takashi Hayashita,
      "Structural Effect of Ditopic Azoprobe-Cyclodextrin Complexes on the Selectivity of Guest-induced Supramolecular Chirality",
      Chem. Commun., 54, 12690-12693 (2018). DOI: 10.1039/C8CC02242A
      Selected as 'Inside Back Cover'
      Inside Back Cover, Chem. Commun., 2018, Issue 90　　　
    3. Yuji Tsuchido, Aya Yamasawa, Takeshi Hashimoto, and Takashi Hayashita,
      "Metal and Phosphate Ion Recognition using Dipicolylamine-Modified Fluorescent Silica Nanoparticles",
      Anal. Sci., 34(10), 1125-1130 (2018). DOI: 10.2116/analsci.18P153
      Selected as 'Hot Article' and 'Front Cover'
      Front Cover, Analytical Sciences, 2018, Issue 10　　　
    4. Adam C. Sedgwick, Wei-Tao Dou, Jin-Biao Jiao, Luling Wu, George T. Williams, A. Toby A. Jenkins, Steven D. Bull, Jonathan L. Sessler, Xiao-Peng He, and Tony D. James,
      "An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates",
      J. Am. Chem. Soc., 140(43), 14267-14271 (2018). DOI: 10.1021/jacs.8b08457
    5. Linyang Chu, Ying Yang, Shengbing Yang, Qiming Fan, Zhifeng Yu, Xi-Le Hu, Tony D. James, Xiao-Peng He, and Tingting Tang,
      "Preferential Colonization of Osteoblasts Over Co-cultured Bacteria on a Bifunctional Biomaterial Surface",
      Front. Microbiol., 9, 2219 (2018). DOI: 10.3389/fmicb.2018.02219
    6. Takeshi Hashimoto,
      "イオン交換・分子認識機能を有する超分子あるいは金属錯体型分析試薬の開発",
      J. Ion Exch., 29(4), 176-187 (2018). （Award Paper） DOI: 10.5182/jaie.29.176
    7. Suzuka Soma, Takahito Suzuki, Tewodros Getachew Bekele, Yuji Tsuchido, Takeshi Hashimoto, and Takashi Hayashita,
      "Design of Saccharide Recognition Material Based on Boronic Acid Fluorophore/Cyclodextrin Gel",
      J. Ion Exch., 29(3), 126-130 (2018). DOI: 10.5182/jaie.29.126
    8. Aya Kitamura, Yuna Kasai, Yuji Tsuchido, Takeshi Hashimoto, and Takashi Hayashita,
      "Design and Function of Fluorescent Silica Nanoparticles for Bacteria Detection",
      J. Ion Exch., 29(3), 121-125 (2018). DOI: 10.5182/jaie.29.121
    9. Luling Wu, Yang Wang, Maria Weber, Liyuan Liu, Adam C. Sedgwick, Steven D. Bull, Chusen Huang, and Tony D. James,
      "ESIPT-based ratiometric fluorescence probe for the intracellular imaging of peroxynitrite",
      Chem. Commun., 54(71), 9953-9956 (2018). DOI: 10.1039/C8CC04919J
    10. Maria Weber, Amanda B. Mackenzie, Steven D. Bull, and Tony D. James,
      "Fluorescence-Based Tool To Detect Endogenous Peroxynitrite in M1-Polarized Murine J774.2 Macrophages",
      Anal. Chem., 90(17), 10621-10627 (2018). DOI: 10.1021/acs.analchem.8b03035
    11. Luling Wu, Qingye Yang, Liyuan Liu, Adam C. Sedgwick, Alexander J. Cresswell, Steven D. Bull, Chusen Huang, and Tony D. James,
      "ESIPT-based fluorescence probe for the rapid detection of hypochlorite (HOCl/ClO−)",
      Chem. Commun., 54(61), 8522-8525 (2018). DOI: 10.1039/C8CC03717E
    12. Maria L. Odyniec, Adam C. Sedgwick, Alexander H. Swan, Maria Weber, T. M. Simon Tang, Jordan E. Gardiner, Miao Zhang, Yun-Bao Jiang, Gabriele Kociok-Kohn, Robert B. P. Elmes, Steven D. Bull, Xiao-Peng He, and Tony D. James,
      "'AND'-based fluorescence scaffold for the detection of ROS/RNS and a second analyte",
      Chem. Commun., 54(61), 8466-8469 (2018). DOI: 10.1039/C8CC04316G
    13. Jebiti Haribabu, Manoharan Muthu Tamizh, Chandrasekar Balachandran, Yuvaraj Arun, Nattamai S. P. Bhuvanesh, Akira Endo, and Ramasamy Karvembu,
      "Synthesis, structures and mechanistic pathways of anticancer activity of palladium(II) complexes with indole-3-carbaldehyde thiosemicarbazones",
      New J. Chem., 42, 10818-10832 (2018). DOI: 10.1039/C7NJ03743K
    14. Tatsuru Yamada, Shoji Fujiwara, Kyohhei Fujita, Yuji Tsuchido, Takeshi Hashimoto, and Takashi Hayashita,
      "Development of Dipicolylamine-Modified Cyclodextrins for the Design of Selective Guest-Responsive Receptors for ATP",
      Molecules, 23(3), 635 (2018). DOI: 10.3390/molecules23030635
      Selected as 'Front Cover'
      Front Cover, Molecules, 2018, Issue 3　　　
    15. Dhrubajyoti Mondal, Mithun Chandra Majee, Sanchita Kundu, Max Mörtel, Ghulam Abbas, Akira Endo, Marat M. Khusniyarov, and Muktimoy Chaudhury,
      "Dinuclear Iron(III) and Cobalt(III) Complexes Featuring a Biradical Bridge: Their Molecular Structures and Magnetic, Spectroscopic, and Redox Properties",
      Inorg. Chem., 57(3), 1004-1016 (2018). DOI: 10.1021/acs.inorgchem.7b02340
2017年
    1. Dhrubajyoti Mondal, Sanchita Kundu, Mithun Chandra Majee, Atanu Rana, Akira Endo, and Muktimoy Chaudhury,
      "Ligand-Induced Tuning of the Oxidase Activity of μ-Hydroxidodimanganese(III) Complexes Using 3,5-Di-tert-butylcatechol as the Substrate: Isolation and Characterization of Products Involving an Oxidized Dioxolene Moiety",
      Inorg. Chem., 56(16), 9448-9460 (2017). DOI: 10.1021/acs.inorgchem.7b00147
    2. Yuji Tsuchido, Shoji Fujiwara, Takeshi Hashimoto, and Takashi Hayashita,
      "Development of Supramolecular Saccharide Sensors Based on Cyclodextrin Complexes and Self-assembling Systems",
      Chem. Pharm. Bull., 65(4), 318-325 (2017). DOI: 10.1248/cpb.c16-00963
    3. Asaithambi Gomathi, Paranthaman Vijayan, Periasamy Viswanathamurthi, Shanmugam Suresh, Raju Nandhakumar, Takeshi Hashimoto,
      "Organoruthenium(II) compounds with pyridyl benzoxazole/benzthiazole moiety: studies on DNA/protein binding and enzyme mimetic activities",
      J. Coord. Chem., 70(10), 1645-1666 (2017). DOI: 10.1080/00958972.2017.1309649
    4. Kyohhei Fujita, Shoji Fujiwara, Tatsuru Yamada, Yuji Tsuchido, Takeshi Hashimoto, and Takashi Hayashita,
      "Design and Function of Supramolecular Recognition Systems Based on Guest-Targeting Probe-Modified Cyclodextrin Receptors for ATP",
      J. Org. Chem., 82(2), 976-981 (2017). DOI: 10.1021/acs.joc.6b02513
      　　Kyohhei Fujita, Shoji Fujiwara, Tatsuru Yamada, Yuji Tsuchido, Takeshi Hashimoto, and Takashi
      　　Hayashita,
      　　Correction to "Design and Function of Supramolecular Recognition Systems Based on Guest-Targeting
      　　Probe-Modified Cyclodextrin Receptors for ATP",
      　　J. Org. Chem., 82(5), 2803-2803 (2017). DOI: 10.1021/acs.joc.7b00233
    5. Sellappan Selvamurugan, Rangasamy Ramachandran, Govindan Prakash, Muthukumaran Nirmala, Periasamy Viswanathamurthi, Shoji Fujiwara, Akira Endo,
      "Ruthenium(II) complexes encompassing 2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazone hybrid ligand: A new versatile potential catalyst for dehydrogenative amide synthesis",
      Inorg. Chim. Acta, 454, 46-53 (2017). DOI: 10.1016/j.ica.2015.12.024
2016年
    1. Yuji Tsuchido, Ryo Sato, Nana Nodomi, Takeshi Hashimoto, Kazunari Akiyoshi, and Takashi Hayashita,
      "Saccharide Recognition Based on Self-assembly of Amphiphilic Phenylboronic Acid Azoprobes",
      Langmuir, 32(41), 10761-10766 (2016). DOI: 10.1021/acs.langmuir.6b02917
    2. Yuna Kasai, Hiroyuki Kobayashi, Yuji Tsuchido, Takeshi Hashimoto, Nobuyuki Kanzawa, and Takashi Hayashita,
      "Staphylococcus aureus Detection by Fluorescent Silica Nanoparticles Modified with Metal-Dipicolylamine Complexes",
      Chem. Lett., 45(7), 749-751 (2016). DOI: 10.1246/cl.160261
    3. Sellappan Selvamurugan, Rangasamy Ramachandran, Paranthaman Vijayan, Rajendran Manikandan, Govindan Prakash, Periasamy Viswanathamurthi, Krishnaswamy Velmurugan, Raju Nandhakumar, and Akira Endo,
      "Synthesis, crystal structure and biological evaluation of Ni(II) complexes containing 4-chromone-N(4)-substituted thiosemicarbazone ligands",
      Polyhedron, 107, 57-67 (2016). DOI: 10.1016/j.poly.2016.01.011
    4. Sellappan Selvamurugan, Rangasamy Ramachandran, Govindan Prakash, Periasamy Viswanathamurthi, Jan Grzegorz Malecki, and Akira Endo,
      "Ruthenium(II) carbonyl complexes containing bidentate 2-oxo-1,2-dihydroquinoline-3-carbaldehyde hydrazone ligands as efficient catalysts for catalytic amidation reaction",
      J. Organomet. Chem., 803, 119-127 (2016). DOI: 10.1016/j.jorganchem.2015.11.017
2015年
    1. Yosuke Hosoya, Takayuki Goto, Akira Endo, Takeshi Hashimoto, Takashi Hayashita, Satoshi Iguchi, and Takahiko Sasaki,
      "NMR Study on the Ru-dimer System with Valence Fluctuation",
      Physics Procedia, 75, 613-617 (2015). DOI: 10.1016/j.phpro.2015.12.078
    2. Kosuke Sugawa, Naoto Takeshima, Koji Uchida, Hironobu Tahara, Shota Jin, Natsumi Tsunenari, Tsuyoshi Akiyama, Yasuyuki Kusaka, Nobuko Fukuda, Hirobumi Ushijima, Yuji Tsuchido, Takeshi Hashimoto, Takashi Hayashita, and Joe Otsuki,
      "Photocurrent Enhancement of Porphyrin Molecules over a Wide-Wavelength Region Based on Combined Use of Silver Nanoprisms with Different Aspect Ratios",
      J. Mater. Chem. C, 3, 11439-11448 (2015). DOI: 10.1039/C5TC02606G
    3. Yuji Tsuchido, and Takashi Hayashita,
      "Development of multipoint molecular recognition systems based on supramolecular formation",
      Dojin News, 154, 1-6 (2015). HTML PDF
    4. Sanchita Kundu, Dhrubajyoti Mondal, Kisholoy Bhattacharya, Akira Endo, Daniele Sanna, Eugenio Garribba, and Muktimoy Chaudhury,
      "Nonoxido Vanadium(IV) Compounds Involving Dithiocarbazate-Based Tridentate ONS Ligands: Synthesis, Electronic and Molecular Structure, Spectroscopic and Redox Properties",
      Inorg. Chem., 54(13), 6203-6215 (2015). DOI: 10.1021/acs.inorgchem.5b00359
    5. Takashi Hayashita,
      "Study on the Development of Supramolecular Complexes Possessing Molecular Recognition and Ion Exchange Functions",
      J. Ion Exch., 26(2), 15-22 (2015). （Award Paper） DOI: 10.5182/jaie.26.15
    6. Yuji Tsuchido, Yuuki Sakai, Keisuke Aimu, Takeshi Hashimoto, Kazunari Akiyoshi, and Takashi Hayashita,
      "Design of phenylboronic acid azoprobe/polyamidoamine dendrimer complexes as a supramolecular sensor for saccharide recognition in water",
      New J. Chem., 39, 2620-2626 (2015). DOI: 10.1039/C4NJ01309C

2015～2024 | 2010～2014 | 2005～2009 | 特許