Publications




Tenma Nakamura, Dinda B. Pitna, Kogaku Kimura, Yukiko Yoshimoto, Tomoya Uchiyama, Takaya Mori, Ryosuke Kondo, Shihori Hara, Yuki Egoshi, Shoya Yamaguchi, Noriyuki Suzuki, Yumiko Suzuki, Toyonobu Usuki
"Total Synthesis of Cynaropicrin"
Organic & Biomolecular Chemistry 2021, Advance Article.

Yuki Mizukawa, Mayumi Ikegami-Kawai, Masako Horiuchi, Marcel Kaiser, Masayoshi Kojima, Seiki Sakanoue, Seiya Miyagi, Christian Nanga Chick, Hiroyuki Togashi, Masayoshi Tsubuki, Masataka Ihara, Toyonobu Usuki, Isamu Itoh
"Quest for a Potent Antimalarial Drug Lead: Synthesis and Evaluation of 6,7-Dimethoxyquinazoline-2,4-diamines"
Bioorganic & Medicinal Chemistry 2021, 33, 116018.

Natsima Viriyaadhammaa, Aroonchai Saiai, Waranya Neimkhum, Wariya Nirachonkul, Wantida Chaiyana, Sawitree Chiampanichayalul, Singkome Tima, Toyonobu Usuki, Suwit Duangmano, Songyot Anuchapreeda
"Cytotoxic Antiproliferative Effects of Diarylheptanoids Isolated from Curcuma comosa Rhizomes on Leukaemic Cells"
Molecules 2020, 25, 5476.

Aisya Syahmina, Toyonobu Usuki
"Ionic Liquid-Assisted Extraction of Essential Oils from Thujopsis dolobrata (Hiba)"
ACS Omega 2020, 5, 29618-29622.

Christian Nanga Chick, Tomoyo Misawa-Suzuki, Yumiko Suzuki, Toyonobu Usuki
"Preparation and Antioxidant Study of Silver Nanoparticles of Microsorum pteropus Methanol Extract"
Bioorganic & Medicinal Chemistry Letters 2020, 30, 127526.

Nao Tanaka, Toyonobu Usuki
"Can Heteroarenes/Arenes Be Hydrogenated over Catalytic Pd/C under Ambient Conditions?"
European Journal of Organic Chemistry 2020, 34, 5514-5522.
【Cover Picture: Cover Feature
【Highlighted in Synfacts 2020, 16, 1462; Synfacts.】

Songyot Anuchapreeda, Riki Anzawa, Natsima Viriyaadhammaa, Waranya Neimkhum, Wanida Chaiyana, Siriporn Okonogi, Toyonobu Usuki
"Isolation and Biological Activity of Agrostophillinol from Kaffir Lime (Citrus hystrix) Leaves"
Bioorganic & Medicinal Chemistry Letters 2020, 30, 127256.

Mika Hirose, Reiko Yokoo, Daisuke Watanabe, Rina Suzuki, Miho Tanigawa, Toyonobu Usuki
"Synthesis of Multi-Deuterated Desmosine"
ChemistrySelect 2020, 5, 3843-3846.

Songyot Anuchapreeda, Fah Chueahongthong, Natsima Viriyaadhammaa, Pawaret Panyajai, Riki Anzawa, Singkome Tima, Chadarat Ampasavate, Aroonchai Saiai, Methee Rungrojsakul, Toyonobu Usuki, Siriporn Okonogi
"Antileukemic Cell Proliferation of Active Compounds from Kaffir Lime (Citrus hystrix) Leaves"
Molecules 2020, 25, 1300.

Daria A. Baut, Nao Tanaka, Reiko Yokoo, Toyonobu Usuki
"Preparation of Isodesmosine-KLH Conjugate for ELISA System"
Chirality 2020, 32, 431-436.
【Special Issue in Memory and Honor of Professor Koji Nakanishi】

Toyonobu Usuki, Yukiko Yoshimoto, Makiko Sato, Tae Takenaka, Ryota Takezawa, Yusuke Yoshida, Masayuki Satake, Noriyuki Suzuki, Daisuke Hashizume, Sergei V. Dzyuba
"Bilobalide and PC12 Cells: A Structure Activity Relationship Study"
Bioorganic & Medicinal Chemistry 2020, 28, 115251.

Jing Li, Yusuke Yoshida, Manami Kurita, Toyonobu Usuki
"Cynaropicrin and Inhibition of NK-κB Activation: A Structure Activity Relationship Study"
Bioorganic & Medicinal Chemistry Letters 2019, 29, 1518-1521.

Wakana Fuse, Akiho Imura, Nao Tanaka, Toyonobu Usuki
"Chichibabin "Isodesmopyridine" Synthesis"
Tetrahedron Letters 2019, 60, 928-930.

Nao Tanaka, Toyonobu Usuki
"Preparation of Protected 13Cn-Labeled Isodesmosines: Mechanistic Insight of Isodesmosine Formation"
Natural Product Communications 2019, 14, 1934578X19849967.

Hitomi Mizuno, Hibiki Yoshikawa, Toyonobu Usuki
"Extraction of Nobiletin and Tangeretin from Peels of Shekwasha and Ponkan using [C2mim][(MeO)(H)PO2] and Centrifugation"
Natural Product Communications 2019, 14, 1934578X19845816.

Akiho Imura, Nao Tanaka, Toyonobu Usuki
"Chichibabin Pyridinium Synthesis"
Tetrahedron Letters 2019, 60, 489-492.

Anna P. Kondo, Takaaki B. Narita, Chihiro Murata, Tetsuhiro Ogura, Ayame Mikagi, Toyonobu Usuki, Tamao Saito
"4-Methyl-5-Pentylbenzene-1,3-Diol Regulates Chemotactic Cell Aggregation and Spore Maturation via Different Mechanisms in Dictyostelium discoideum"
Current Microbiology 2019, 76, 376-381.

Quang Thuong Tran, Loan Thi Thanh Vu, Tram Huyen Le, Ly Thi Phuong Giang, Toyonobu Usuki
"Box-Behnken Experimental Design for the Extraction of Spinosin from Ziziphus mauritiana Lam. Seeds"
Asian Journal of Chemistry 2019, 31, 1045-1048.

Songyot Anuchapreeda, Nattakanwadee Khumpirapang, Sawitree Chiampanichayakul, Wariya Nirachonkul, Aroonchai Saiai, Toyonobu Usuki, Siriporn Okonogi
"Characterization and Biological Properties of Zederone and Zedoarondiol from Rhizomes of En-Lueang (Curcuma cf. amada)"
Natural Product Communications 2018, 13, 1615-1618.

Toyonobu Usuki, Masahiro Yoshizawa-Fujita
"Extraction and Isolation of Natural Organic Compounds from Plant Leaves Using Ionic Liquids" in Advances in Biochemical Engineering/Biotechnology 2018
Springer, Berlin, Heidelberg

Ayame Mikagi, Dai Tokairin, Toyonobu Usuki
"Suzuki-Miyaura Cross-Coupling Reaction of Monohalopyridines and L-Aspartic Acid Derivative"
Tetrahedron Letters 2018, 59, 4602-4605.

Nao Tanaka, Manami Kurita, Yuko Murakami, Toyonobu Usuki
"Chichibabin and IsoChichibabin Pyridinium Syntheses of Isodesmosine, Desmosine, and their Derivatives"
European Journal of Organic Chemistry 2018, 21, 6002-6009.

臼杵 豊展
"ボーダーレス天然物化学"
有機合成化学協会誌 2018, 76, 422-425.

Hitomi Mizuno, Toyonobu Usuki
"Ionic Liquid-Assisted Extraction and Isolation of Cynaropicrin and Cnicin from Artichoke and Blessed Thistle"
ChemistrySelect 2018, 3, 1781-1786.

Songyot Anuchapreeda, Nattakanwadee Khumpirapang, Kawinnat Rupitiwiriya, Leelawat Tho-iam, Aroonchai Saiai, Siriporn Okonogi, Toyonobu Usuki
"Cytotoxicity and Inhibition of Leukemic Cell Proliferation by Sesquiterpenes from Rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.)"
Bioorganic & Medicinal Chemistry Letters 2018, 28, 410-414.

Toyonobu Usuki, Shingo Onda, Masahiro Yoshizawa-Fujita, Masahiro Rikukawa
"Use of [C4mim]Cl for Efficient Extraction of Caffeoylquinic Acids from Sweet Potato Leaves"
Scientific Reports 2017, 7, 6890.

Toyonobu Usuki, Koki Munakata
"Extraction of Essential Oils from the Flowers of Osmanthus fragrans var. aurantiacus Using an Ionic Liquid"
Bulletin of the Chemical Society of Japan 2017, 90, 1105-1110.

Toyonobu Usuki, Akira Komatsu
"Preparation of Monoalkylpiperidines via the Mild Hydrogenation of Monoalkynylpyridines"
Tetrahedron Letters 2017, 58, 2856-2858.
【Highlighted in Synfacts 2017, 13, 1224; Synfacts.】

Keita Ogawa, Takahiro Hayashi, Yong Y. Lin, Toyonobu Usuki
"Synthesis of Desmosine-Containing Cyclic Peptide for the Possible Elucidation of Elastin Crosslinking Structure"
Tetrahedron 2017, 73, 3838-3847.

Daisuke Watanabe, Rina Suzuki, Toyonobu Usuki
"Synthesis of Desmosine-d4: Improvement of Isotopic Purity by D-H Exchange of Amino Groups"
Tetrahedron Letters 2017, 58, 1194-1197.

Koki Munakata, Masahiro Yoshizawa-Fujita, Masahiro Rikukawa, Toyonobu Usuki
"Improved Extraction Yield of Citral from Lemon Myrtle Using a Cellulose-Dissolving Ionic Liquid"
Australian Journal of Chemistry 2017, 70, 699-704.

Chihiro Murata, Masahiro Yoshizawa-Fujita, Masahiro Rikukawa, Toyonobu Usuki
"Extraction of Essential Oils from Lemongrass Using Ionic Liquid"
Asian Journal of Chemistry 2017, 29, 309-312.

Jiangtao He, Shuren Ma, Jerome Cantor, Toyonobu Usuki, Georgia Dolios, Rong Wang, Gerard M. Turino, Yong Y. Lin
"Degradation of Human Lung Elastin Matrix"
Current Topics in Peptide & Protein Research 2016, 17, 105-124.

Manami Kurita, Miho Tanigawa, Shuhei Narita, Toyonobu Usuki
"Synthetic Study of Cnicin: Synthesis of the Side Chain and its Esterification"
Tetrahedron Letters 2016, 57, 5899-5901.

Chihiro Murata, Quang Thuong Tran, Shingo Onda, Toyonobu Usuki
"Extraction and Isolation of Ganoderic Acid S from Ganoderma lucidum"
Tetrahedron Letters 2016, 57, 5368-5371.

Chihiro Murata, Tetsuhiro Ogura, Shuhei Narita, Anna P. Kondo, Natsumi Iwasaki, Tamao Saito, Toyonobu Usuki
"Synthesis and SAR of 4-Methyl-5-Pentylbenzen-1,3-Diol (MPBD), Produced by Dictyostelium discoideum"
Bioorganic & Medicinal Chemistry Letters 2016, 26, 1428-1433.

Takuya Sato, Shihori Hara, Makiko Sato, Keita Ogawa, Michael Adams, Toyonobu Usuki
"Synthesis of Cynaropicrin-d4"
Bioorganic & Medicinal Chemistry Letters 2015, 25, 5504-5507.

Ayano Tanaka-Yanuma, Satoshi Watanabe, Keita Ogawa, Sho Watanabe, Naoto Aoki, Tetsuhiro Ogura, Toyonobu Usuki
"Synthesis of the Polyketide Moiety of the Jamaicamides"
Tetrahedon Letters 2015, 56, 6777-6781.

Shingo Onda, Toyonobu Usuki, Masahiro Yoshizawa-Fujita, Masahiro Rikukawa
"Ionic Liquid-Mediated Extraction of Bilobalide from Ginkgo biloba Leaves"
Chemistry Letters 2015, 44, 1461-1463.

Yohei Koseki, Takanori Sugimura, Keita Ogawa, Rina Suzuki, Haruka Yamada, Noriyuki Suzuki, Yoshiro Masuyama, Yong Y. Lin, Toyonobu Usuki
"Total Synthesis of Isodesmosine by Stepwise, Regioselective Negishi and Sonogashira Cross-Coupling Reactions"
European Journal of Organic Chemistry 2015, 18, 4024-4032.

Takahiro Tanigawa, Akira Komatsu, Toyonobu Usuki
"[13C3,15N1]-Labeled Isodesmosine: a Potential Internal Standard for LC-MS/MS Analysis of Demosines in Elastin Degradation"
Bioorganic & Medicinal Chemistry Letters 2015, 25, 2046-2049.

Rina Suzuki, Hiroto Yanuma, Takahiro Hayashi, Haruka Yamada, Toyonobu Usuki
"Syntheses of Natural and Deuterated Desmosines via Palladium-Catalyzed Cross-Coupling Reactions"
Tetrahedron 2015, 71, 1851-1862.

Haruka Yamada, Takahiro Hayashi, Toyonobu Usuki
"Total Synthesis of the COPD Biomarker Desmosine via Stepwise Sonogashira Cross-Coupling Reactions"
Bulletin of the Chemical Society of Japan 2015, 88, 673-683.

Yuko Murakami, Rina Suzuki, Hiroto Yanuma, Jiantao He, Shuren Ma, Gerard M. Turino, Yong Y. Lin, Toyonobu Usuki
"Synthesis and LC-MS/MS Analysis of Desmosine-CH2, a Potential Internal Standard for the Degraded Elastin Biomarker Desmosine"
Organic & Biomolecular Chemistry 2014, 12, 9887-9894.

Takanori Sugimura, Akira Komatsu, Yohei Koseki, Toyonobu Usuki
"Pr(OTf)3-promoted Chichibabin Pyridine Synthesis of Isodesmosine in H2O/MeOH"
Tetrahedon Letters 2014, 55, 6343-6346.

Stefanie Zimmermann, Gerda Fouche, Maria De Mieri, Yukiko Yoshimoto, Toyonobu Usuki, Rudzani Nthambeleni, Christopher J. Parkinson, Christiaan van der Westhuyzen, Marcel Kaiser, Matthias Hamburger, Michael Adams
"Structure-Activity Relationship Study of Sesquiterpene Lactones and Their Semi-Synthetic Amino Derivatives as Potential Antitrypanosomal Products"
Molecules 2014, 19, 3523-3538.

Toyonobu Usuki, Takanori Sugimura, Akira Komatsu, Yohei Koseki
"Biomimetic Chichibabin Pyridine Synthesis of the COPD Biomarkers and Elastin Cross-Linkers Isodesmosine and Desmosine"
Organic Letters 2014, 16, 1672-1675.

Toyonobu Usuki, Makiko Sato, Shihori Hara, Yukiko Yoshimoto, Ryosuke Kondo, Stefanie Zimmermann, Marcel Kaiser, Reto Brun, Matthias Hamburger, Michael Adams
"Antitrypanosomal Structure-Activity-Relationship Study of Synthetic Cynaropicrin Derivatives"
Bioorganic & Medicinal Chemistry Letters 2014, 24, 794-798.

Toyonobu Usuki, Hiroto Yanuma, Takahiro Hayashi, Haruka Yamada, Noriyuki Suzuki, Yoshiro Masuyama
"Improved Negishi Cross-Coupling Reactions of an Organozinc Reagent Derived from L-Aspartic Acid with Monohalopyridines"
Journal of Heterocyclic Chemistry 2014, 51, 269-273.

Yuki Egoshi, Ryosuke Kondo, Yukiko Yoshimoto, Toru Sugiyama, Toyonobu Usuki
"Improved Synthesis of (R)-7-Hydroxycarbone from (S)-a-Pinene"
Tetrahedron Letters 2013, 54, 7029-7030.

臼杵 豊展
"COPDバイオマーカー診断法の確立を目指したエラスチン架橋アミノ酸類の創製"
有機合成化学協会誌 2013, 71, 891-899.

Shuren Ma, Gerard M. Turino, Takahiro Hayashi, Hiroto Yanuma, Toyonobu Usuki, Yong Y. Lin
"Stable Deuterium Internal Standard for the Isotope-Dilution LC-MS/MS Analysis of Elastin Degradation"
Analytical Biochemistry 2013, 440, 158-165.

Satoshi Watanabe, Sho Watanabe, Naoto Aoki, Toyonobu Usuki
"Synthesis of the Polyketide (E)-Olefin of the Jamaicamides"
Synthetic Communications 2013, 43, 1397-1403.

Tetsuhiro Ogura, Toyonobu Usuki
"Total Synthesis of Acerogenins E, G and K, and Centrolobol"
Tetrahedron 2013, 69, 2807-2815.

Hiroto Yanuma, Toyonobu Usuki
"Synthesis of Neodesmosine, a Crosslinking Pyridinium Amino Acid of Elastin, via a Negishi Cross-Coupling"
Heterocycles 2013, 87, 55-63.

Shuhei Narita, Tetsuhiro Ogura, Toyonobu Usuki
"Synthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura Reaction"
Journal of Chemistry 2013, 2013, 686242 (5 pages).

Yuko Murakami, Hiroto Yanuma, Toyonobu Usuki
"Total Synthesis of the Elastin Crosslinker (+)-Desmopyridine"
Tetrahedron: Asymmetry 2012, 23, 1557-1563.

Hiroto Yanuma, Toyonobu Usuki
"Total Synthesis of the COPD Biomarker Desmosine via Sonogashira and Negishi Cross-Coupling Reactions"
Tetrahedron Letters 2012, 53, 5920-5922.

Toyonobu Usuki, Haruka Yamada, Takahiro Hayashi, Hiroto Yanuma, Yohei Koseki, Noriyuki Suzuki, Yoshiro Masuyama, Yong Y. Lin
"Total Synthesis of COPD Biomarker Desmosine that Crosslinks Elastin"
Chemical Communications 2012, 48, 3233-3235.

Tohru Taniguchi, Toyonobu Usuki
"Circular Dichroism Spectroscopy" in Supramolecular Chemistry: From Molecules to Nanomaterials
Edited by Jonathan W. Steed, Philip A. Gale
John Wiley & Sons Ltd, Chichester, UK, 2012, pp 393-410.

Hiroshi Goto, Toyonobu Usuki
"1H-NMR Analysis of Terpene Trilactones (TTLs) in Ginkgo Biloba: Green Female Leaves Contain the Most TTLs"
Phytochemical Analysis 2012, 23, 84-87.

Toyonobu Usuki, Nanae Yasuda, Masahiro Yoshizawa-Fujita, Masahiro Rikukawa
"Extraction and Isolation of Shikimic Acid from Ginkgo Biloba Leaves Utilizing an Ionic Liquid that Dissolves Cellulose"
Chemical Communications 2011, 47, 10560-10562.
【Featured on the website of the Royal Society of Chemistry magazine Chemistry World.】

Ayano Tanaka, Toyonobu Usuki
"Synthesis of the Peptide Moiety of the Jamaicamides"
Tetrahedron Letters 2011, 52, 5036-5038.

Etsuko Suzuki, Makiko Sato, Ryota Takezawa, Toyonobu Usuki, Takashi Okada
"The Facilitative Effects of Bilobalide, a Unique Constituent of Ginkgo Biloba, on Synaptic Transmission and Plasticity in Hippocampal Subfields"
The Journal of Physiological Science 2011, 61, 421-427.

Yohei Koseki, Haruka Yamada, Toyonobu Usuki
"Efficient Synthesis of Benzyl 2-(S)-[(tert-Butoxycarbonyl)amino]-w-Iodoalkanoates"
Tetrahedron: Asymmetry 2011, 22, 580-586.

Ayano Tanaka, Yasuhiro Arai, Su-Nam Kim, Jungyeob Ham, Toyonobu Usuki
"Synthesis and Biological Evaluation of Bilobol and Adipostatin A"
Journal of Asian Natural Products Research 2011, 13, 290-296.

Toyonobu Usuki, Mari Kawai, Koji Nakanishi, George A. Ellestad
"Calicheamicin g1I and Phenyl tert-Butyl Nitron (PBN): Observation of a Kinetic Isotope Effect by an ESR Study"
Chemical Communications 2010, 46, 737-739.

Masayuki Inoue, Nayoung Lee, Keisuke Miyazaki, Toyonobu Usuki, Shigeru Matsuoka, Masahiro Hirama
"Critical Importance of the Nine-Membered F Ring of Ciguatoxin for Potent Bioactivity: Total Synthesis and Biological Evaluation of F-Ring-Modified Analogues"
Angewandte Chemie International Edition 2008, 47, 8611-8614.

Toyonobu Usuki, Koji Nakanishi, George A. Ellestad
"Spin-Trapping of the p-Benzyne Intermediates from Ten-Membered Enediyne Calicheamicin g1I"
Organic Letters 2006, 8, 5461-5463.

Masahiro Hirama, Kimio Akiyama, Parthasarathi Das, Takashi Mita, Martin J. Lear, Kyo-ichiro Iida, Itaru Sato, Fumihiko Yoshimura, Toyonobu Usuki, Shozo Tero-Kubota
"Direct Observation of ESR Spectra of Bicyclic Nine-Membered Enediynes at Ambient Temperature"
Heterocycles 2006, 69, 83-89.

Masayuki Inoue, Toyonobu Usuki, Nayoung Lee, Masahiro Hirama, Toshiyuki Tanaka, Fumihito Hosoi, Shinji Ohie, Toshio Otani
"Antitumor Enediyne Chromoprotein C-1027: Mechanistic Investigation of the Chromophore-Mediated Self-Decomposition Pathway"
Journal of the American Chemical Society 2006, 128, 7896-7903.

Toyonobu Usuki, Masayuki Inoue, Kimio Akiyama, Masahiro Hirama
"ESR Studies on DNA Cleavage Induced by Enediyne C-1027 Chromophore"
Bioorganic & Medicinal Chemistry 2005, 13, 5218-5224.

Toyonobu Usuki, Takashi Mita, Martin J. Lear, Parthasarathi Das, Fumihiko Yoshimura, Masayuki Inoue, Masahiro Hirama, Kimio Akiyama, Shozo Tero-Kubota
"Spin Trapping of 13C-Labeled p-Benzynes Generated by Masamune-Bergman Cyclization of Bicyclic Nine-Membered Enediynes"
Angewandte Chemie International Edition 2004, 43, 5249-5253.

Toyonobu Usuki, Masayuki Inoue, Masahiro Hirama, Toshiyuki Tanaka
"Rational Design of a Supra C-1027: Kinetically Stabilized Analogue of the Antitumor Enediyne Chromoprotein"
Journal of the American Chemical Society 2004, 126, 3022-3023.

Toyonobu Usuki, Masayuki Inoue, Kimio Akiyama, Masahiro Hirama
"Spin-trapping Study of DNA Cleavage Induced by Enediyne C-1027 Chromophore"
Chemistry Letters 2002, 31, 1148-1149.



Patents

臼杵豊展、田中尚 「環状化合物の製造方法」
特願2019-194685、2019年10月25日出願

臼杵豊展 「弾性繊維損傷マーカーの解析」
特願2018-206695、6436401、2018年11月1日出願

臼杵豊展、水野瞳、吉川響 「フラボノイドの抽出方法及び単離方法」
特願2018-089207、2018年5月7日出願

臼杵豊展 「同位体標識化合物の製造方法」
特願2018-086606、2018年4月27日出願

臼杵豊展 「複合体」
特願2018-054389、2018年3月22日出願

臼杵豊展 「デスモシンおよびイソデスモシンの製造方法」
特願2017-243119、2017年12月19日出願

臼杵豊展 「Process for Preparing Deuterium Isotope of Desmosine and Derivatives Thereof」
特許10,280,143、2017年11月13日出願

臼杵豊展、水野瞳 「テルペン類の抽出方法」
特願2017-159612、2017年8月22日出願

臼杵豊展 「ピぺリジン化合物の製造方法」
特願2016-119877、特許6744622、2016年6月16日出願

Yong Y. Lin, Shuren Ma, Gerard M. Turino, Toyonobu Usuki 「弾性繊維損傷マーカーの解析」
PCT/US2014/036070、WO2014179408、特許6436401、2014年4月30日出願

臼杵豊展、藤田正博、音田慎吾 「カフェオイルキナ酸類抽出方法及びカフェオイルキナ酸類製造方法」
特願2014-092037、特許6466081、2014年4月25日出願

臼杵豊展 「化合物、これを用いた定量分析用標準物質およびデスモシン類の定量方法」
特願2014-055337、特許6233929、2014年3月18日出願

Toyonobu Usuki 「Method for Producing Desmosine, Isodesmosine, and Derivatives」
PCT/JP2014/051482、特許9556119、2014年1月24日出願

臼杵豊展 「デスモシン、イソデスモシン、およびその製造方法」
特願2013-018473、特許6233934、2013年2月1日出願

臼杵豊展、藤田正博、保田菜々絵 「シキミ酸取得方法及びシキミ酸製造方法」
特願2011-052211、特許5737751、2011年3月9日出願

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